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| Influence of preemptive analgesia by dexmedetomidine during laparoscopic hysterectomy on postoperative pain and the expression of their serum exosome long non-coding RNA colon cancer associated transcript 1 |
| The Third Affiliated Hospital of Zhengzhou University, Henan Province, 450052 |
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Abstract To investigate the influence of preemptive analgesia by dexmedetomidine for treating women during laparoscopic hysterectomy on their postoperative pain and the expressions of their serum exosome long non-coding RNA colon cancer associated transcript 1 (lncRNA CCAT1). Methods: From June 2018 to March 2020, 80 women who wanted laparoscopic hysterectomy were selected as the research objects, and were randomly divided into two groups according to the random number table. 40 women in the control group were given conventional analgesia, while 40 women in the study group were given dexmedetomidine for preemptive analgesia. The visual analogue scale (VAS) score, Ramsay score, the serum lncRNA CCAT1 expression, and the adverse reactions of the women in the two groups were observed. Results: VAS score and Ramsay score of the women in the two groups had no significant different among the different postoperative time points (P>0.05), but VAS score of the women in the study group at 4h, 8h, 12h, or 24h after surgery was significantly lower than that of the women in the control group, and Ramsay score of the women in the study group at 4h, 8h, 12h, or 24h after surgery was significantly higher than that of the women in the control group (P<0.05). The expression level of the serum exosomes lncRNA CCAT1 (0.54±0.22) of the women in the study group after operation was significantly lower than that (0.96±0.31) of the women in the control group (P<0.05). There was no significant difference in the incidence of postoperative bradycardia (0 vs.5.0%) of the women between the two groups, and the incidences of nausea (7.5%) and vomiting (5.0%) of the women in the study group were significantly lower than those (27.5% and 20.0%) of the women in the control group (P<0.05). Conclusion: Preemptive analgesia by dexmedetomidine for treating women during laparoscopic hysterectomy can effectively relieve the pain, enhance the analgesic effect, reduce the expression level of serum lncRNA CCAT1 after operation, and reduce the occurrence of adverse reactions.
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