|
|
|
| Relationship between the value of quantitative indexes of ultrasound contrast of the patients with endometrial carcinoma and the expression levels of serum matrix metalloproteinases and vascular endothelial growth factor |
| West Coast New District People's Hospital, Qingdao, Shandong Province, 266400 |
|
|
|
|
Abstract To explore the relationship between the value of quantitative indexes of ultrasound contrast of the patients with endometrial carcinoma and the expression levels of matrix metalloproteinase(MMP) 2, MMP9, and vascular endothelial growth factor(VEGF) of the patients. Methods: 60 patients with endometrial cancer diagnosed by pathology were selected in group A, and 60 patients with hysteromyoma undergoing surgical resection were selected in group B from April 2018 to June 2020. The expression levels of MMP2, MMP9, and VEGF in excision tissues were detected by enzyme-linked immunosorbent assay(ELISA). The quantitative indexes of ultrasound contrast were monitored by color Doppler echocardiography. Pearson method was used to analyze the relationship between the value of quantitative indexes of ultrasound contrast and the expression levels of MMP 2, MMP9, and VEGF of the patients. Logistic regression analysis was used to analyze the influencing factors of endometrial cancer. Results: The values of mean transit time(MTT), and peak intensity(PI) of the patients in group A were significantly higher than those of the patients in group B(P<0.05), but the time to peak(TTP) of the patients in group A was significantly lower(P<0.05). The expression levels of MMP2, MMP9, and VEGF in endometrial carcinoma tissues of the patients in group A were significantly higher than those of the patients in group B(all P<0.05). The expression levels of MMP2, MMP9, and VEGF of the patients with pathological stages Ⅲ-Ⅳ, with lymph node metastasis, or with myometrial invasion >1/2 were significantly higher than those of the patients with pathological stagesⅠ-Ⅱ, without lymph node metastasis, or with myometrial invasion ≤1/2(P<0.05). The expression levels of MMP2, MMP9, and VEGF of the patients with endometrial carcinoma were positively correlated with their MTT value(P<0.05), but which were negatively correlated with their TTP value. The expression levels of MMP9 and VEGF of the patients with endometrial carcinoma were positively correlated with their PI value(all P<0.05). The MMP2 level of the patients with endometrial carcinoma was not significantly correlated to the PI value(P>0.05). The high expression levels of MMP2, MMP9, and VEGF of the patients were the risk factor of endometrial carcinoma. Conclusion: The expression levels of MMP2, MMP9, and VEGF in endometrial carcinoma tissues of the patients increase, which are closely related to the values of quantitative indexes of ultrasound contrast. It is suggested that the values of quantitative indexes of ultrasound contrast can reflect the expression levels of MMP2, MMP9, and VEGF in endometrial carcinoma tissues of the patients, which can provide certain reference for evaluating the condition of patients with endometrial carcinoma.
|
|
|
|
|
|
|
|
|
