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| Analysis of the conversion and the influence factors of glucose metabolism of women with gestational diabetes mellitus 1 years after delivery |
| 1. The Second Maternal and Child Health Care Hospital of Huizhou, Guangdong Province, 516001; 2. The Third People's Hospital of Huizhou |
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Abstract To evaluate the conversion situation of glucose metabolism of women with gestational diabetes mellitus(GDM) within 6-8 weeks and 1 year after delivery, and to study the influencing factors of the conversion failure of abnormal glucose metabolism of the women after delivery. Methods: 100 women who had been diagnosed as GDM during pregnancy from January 2019 to January 2020 were selected as study objects. 75g oral glucose tolerance test of these women was performed in 6-8 weeks and 1 year after delivery. Based on the postpartum glucose metabolism indexes, these 100 women were divided in normal glycometabolism group and abnormal glycometabolism group. The influence factors of abnormal glucose metabolism were analyzed. Results: When 6-8 weeks after delivery, there were 45(45.0%) women with abnormal glucose metabolism, which included 14(14.0%) women with diabetes, 21(21.0%) women with impaired glucose tolerance(IGT), and 10(10.0%) women with impaired fasting glucose(IFG). 1 year after delivery, there were 42(42.0%) women with abnormal glucose metabolism, which included 15(15.0%) women with diabetes, 18(18.0%) women with IGT, and 9(9.0%) women with IFG. The cumulative incidence of diabetes of the women within 1 year after delivery was 15.0%(15/100). Logistic multivariate stepwise regression analysis showed that the risk of conversion failure of abnormal glucose metabolism of the women with body mass index≥28kg/m2 during pregnancy, with early gestational weeks when GDM diagnosis, with higher 1h PG level, or with higher insulin resistance index(HOMA-IR) in 1 year after delivery was higher(P<0.05). Conclusion: The rate of abnormal glucose metabolism of the women with GDM in 1 year after delivery is high, so it should be paid more attention to the risk factors of postpartum short-term glucose metabolism conversion failure in clinic.
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