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| Influence of ultrasound-guided transversus abdominisplane combined with diclofenac sodium suppository for anesthesia during laparoscopic hysterectomy of the patients on their cognition level, and plasma interleukin-6, C-reactive protein, cortisol levels |
| Jiangning Hospital of Nanjing, Jiangsu Province, 21110 |
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Abstract To explore the clinical analgesic effect of ultrasound-guided transversus abdominisplane(TAP) block combined with diclofenac sodium suppository during laparoscopic hysterectomy, and to analyze its influence on cognitive level, and plasma interleukin-6(IL-6), C-reactive protein(CRP), cortisol(Cor) levels of patients. Methods: 100 patients who had undergone laparoscopic hysterectomy were selected as the research objects from October 2018 to October 2020. These patients were divided in observation group and control group(50 cases in each group) by the odd and even number labeling method. The patients in the control group had received ultrasound-guided TAP block anesthesia, and the patients in the observation group had received ultrasound-guided TAP block combined with diclofenac sodium suppository. The surgical indicators of the patients in the two groups were recorded. The differences of postoperative pain, cognitive function, and plasma IL-6, CRP, and Cor levels of the patients in the two groups were analyzed. Results: The dosage of postoperative fentanyl used, the spontaneous breathing recovery time, the wake-up time, and the time to get out of bed of the patients in the observation group were significantly less than those of the patients in the control group(P<0.05). In 48 hours after operation, the VAS scores of the patients in the two groups all had showed a trend of decreasing-increasing-decreasing, but the pain degree of the patients in the observation group was significantly lower than that of the patients in the control group(P<0.05). Compared with those before anesthesia, the levels of Tau protein, Tau/Aβ-42 value, and the IL-6, CRP, Cor levels of the patients in the two groups at 48 hours after operation had increased significantly, but the Aβ-42 level of the patients in the two groups had decreased significantly. At 48h after operation, the Tau protein level, Tau/Aβ-42 value, and the levels of IL-6, CRP, and Cor of the patients in the observation group were significantly lower than those of the patients in the control group(P<0.05). Conclusion: Ultrasound-guided TAP block combined with diclofenac sodium suppository for anesthesia during operation can improve intraoperative and postoperative anesthetic effect, decrease pain degree of the patients, reduce the negative impact of anesthesia on nerve function of the patients, and promote postoperative recovery of the patient.
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