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| The correlation and predictive value of levels of the interleukin-17 and interleukin 17 of T cell subsets of pregnant women with syphilis for their adverse pregnancy outcomes |
| Futian District Chronic Disease Control Hospital, Shenzhen, Guangdong Province, 518000 |
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Abstract To explore the correlation and diagnostic value of interleukin-17 (IL-17) and interleukin 17 levels of T cell subsets (Th17) of the pregnant women with syphilis for their adverse pregnancy outcomes. Methods: 244 pregnant women with syphilis from January 2016 to December 2019 were selected and were divided into group A (110 women with low titer of serum TRUST) and group B (14 women with high titer of serum TRUST), and 120 healthy pregnant women were selected in control group. The influencing factors of adverse pregnancy outcomes of the pregnant women with syphilis were analyzed, and the diagnostic value of Th17 and IL-17 levels were also analyzed. Results: The levels of Th17 and IL-17 of the women in group A and group B were significant higher than those of the women in the control group (P＜0.01), but which of the women had no significant different between group B and group A (P＞0.05). The incidence of adverse pregnancy outcomes (22 cases, 17.7%) of the women in group A and group B was significant higher than that (2 cases, 1.7%) of the women in the control group (P＜0.05). The Th17 and IL-17 levels were the independent risk factors of adverse pregnancy outcomes of the pregnant women with syphilis (P＜0.05). AUC of Th17 level of the women for predicting their adverse pregnancy outcome was 0.964, and which of IL-17 level was 0.975. Conclusion: The levels of Th17 cells in peripheral blood and serum IL-17 of the pregnant women with syphilis are significant higher than those of the healthy pregnant women, and the incidence of adverse pregnancy outcomes of the pregnant women with syphilis is also significant higher than that of the healthy pregnant women. The levels of Th17 and IL-17 have higher diagnostic value for adverse pregnancy outcomes of the pregnant women with syphilis.
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