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Abstract To explore the application value of miR-146a, soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1), and homocysteine (HCY) of pregnant women for diagnosing their pregnancy-induced hypertension and renal dysfunction. Methods: The clinical data of 119 pregnant women from May 2018 to June 2020 were selected for retrospective analysis. These women were divided into observation group (n=69) and control group (n=50) according to the presence or absence of pregnancy-induced hypertension. In the observation group, the women were divided into group A (25 women with pregnancy-induced hypertension), group B (25 women with mild preeclampsia), and group C (19 women with severe preeclampsia) according to the severity of pregnancy-induced hypertension. According to the creatinine clearance rate (Ccr), the women in the observation group were also divided into group D (35 women with Ccr＜80ml/min) and group E (34 women with Ccr≥80ml/min). Results: The levels of Mir-146a, SLOx-1, and HCY of the women in the observation group were significant higher than those of the women in the control group, which of the women in group C were significant higher than those of the women in groups B and A, and which of the women in group C were significant higher than those of the women in group E (all P<0.05). Spearman correlation analysis showed that the levels of Mir-146a, Slox-1, and HCY of the women were positively correlated with the severity of their pregnancy-induced hypertension, and mir-146a and Slox-1 levels of the women were positively correlated with their HCY level (all P<0.05). ROC curve analysis showed that the AUC of Mir-146a level, SLOx-1 level, HCY level, and the combined of the levels of Mir-146a, SLOx-1, and HCY for diagnosing the renal function impairment of the women with pregnancy-induced hypertension were 0.908, 0.950, 0.916, and 0.962, respectively (P<0.05), which sensitivity were 88.6%, 91.4%, 82.9%, and 88.6%, respectively, and which specificity were 85.3%, 97.1%, 94.1%, and 100.0%, respectively. Conclusion: MiR-146a, sLOX-1, and HCY of the pregnant women are involved in their occurrence and development of pregnancyinduced hypertension. The combined detections of miR-146a, sLOX-1, and HCY levels of the pregnant women with pregnancy-induced hypertension for predicting their renal function impairment has higher effect.
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