|
|
|
| Correlation between different menstrual cycles of patients with polycystic ovary syndrome and their glucose and lipid metabolism and islet function |
| The Second Hospital Affiliated to Suzhou University, Jiangsu Province, 215000 |
|
|
|
|
Abstract To analyze the differences of glucose and lipid metabolism and islet function of patients with polycystic ovary syndrome (PCOS) and with different model of menstrual cycles. Methods: A total of 328 patients with PCOS were selected as the research subjects from March 2018 to September 2020. According to their menstrual cycle, these patients were divided into group A (24 cases with frequent menstruation and irregular vaginal bleeding), group B (30 cases with regularity menstruation), group C (155 cases with sparse menstruation), and group D (119 cases with amenorrhea). The clinical characteristics, sex hormone levels, glucose and lipid metabolism, and islet function of the patients were compared among the four groups. The correlation between menstrual cycle of the patients and their hyperlipidemia and insulin resistance was analyzed. Results: The body mass index (BMI), the hip ratio (WHR), and the incidence of hairy of the patients in group C and group D were significant higher than those of the patients in group A and group B (P<0.05), and the WHR of the patients in group D was significant higher than that of the patients in group C (P<0.05). The levels of luteinizing hormone (LH) and testosterone (T), and the value of LH/FSH (folliclestimulating hormone) of the patients in group D were significant higher than those of the patients in group C, and which of the patients in group C and group D were significant higher than those of the patients in group A and group B (P<0.05). The levels of fasting plasma glucose (FPG), fasting insulin (FINS), total cholesterol (TC), and triglyceride (TG) of the patients in group C and group D were significant higher than those of the patients in group A and group B (P<0.05), but the HDL level of the patients in group C and group D was significant lower (P<0.05). The FINS level of the patients in group D was significant higher than that of the patients in group C, but the HDL level of the patients in group D was significant lower (P<0.05). The value of HOMA-IR of the patients in group C and group D were significant higher than those of the patients in group A and group B, but the value of HOMA-β of the patients in group C and group D was significant lower (P<0.05). There were no significant differences in the values of HOMA-IR and HOMA-βof the patients between group C and group D, and between group A and group B (P>0.05). BMI, WHR, sparse menstruation, and amenorrhea were the independent influence factors of hyperlipidemia of the patients, and age, BMI, WHR, sparse menstruation, and amenorrhea were the independent factors affecting insulin resistance of the patients (all P<0.05). Conclusion: The degree of glycolipid metabolism disorder and islet function decreasing of the patients with PCOS and sparse menstruation or amenorrhea is more severe, and the risk of hyperlipidemia and insulin resistance of these patients is higher.
|
|
|
|
|
|
|
|
|
