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| Efficacy and mechanism of baofukang suppository combined with xinfuning for treating women with humanpapilloma virus infection |
| 1.The First People's Hospital of Anqing, Anhui Province, 246000; 2.ShaAnxi Tuberculosis Hospital(The Fifth People's Hospital of Shaanxi Province |
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Abstract To observe the efficacy and mechanism of baofukang suppository combined with xinfuning for treating women with humanpapilloma virus (HPV) infection. Methods: 218 women with HPV infection were selected as subjects and were divided in two groups by random number table method from July 2018 to July 2020. 109 women in the control group were treated with xinfuning, and 109 women in the observation group were treated with baofukang suppository combined with xinfuning. The immune function ［the number of T lymphocyte subsets (CD3+, CD4+, CD4+/CD8+) and Foxp3+ Tregs, and the levels of immunoglobulins (IgA, IgG, IgM)］, the levels changes of inflammation indicators ［tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6), interleukin-2 (IL-2)］ of the women in the two groups were observed. The HPV conversion rate of the women was statistics analyzed. The clinical efficacy and safety of these women were evaluated, and their recurrence rate was followed up for 6 months. Result: After treatment, the numbers of T lymphocyte subsets (CD3+, CD4+, CD4+/CD8+) and Foxp3+Tregs, and the levels of immunoglobulin (IgA, IgG, IgM) of the women in the two groups had increased significantly, and which of the women in the observation group were significant higher than those of the women in the control group. The levels of TNF-α, IL-6 and IL-2 of the women in the two groups had decreased significantly, and which of the women in the observation group were significant lower than those of the women in the control group (all P<0.05). The HPV negative conversion rate (93.6%) and total effective rate (95.4%) of the women in the observation group were significant higher than those (82.6% and 87.2%) of the women in the control group (P<0.05). There was no significant difference in the rate of adverse reactions (7.3% vs. 6.4%) of the women between the two groups (P=0.982). The recurrence rate (1.8%) of the women in the observation group was significant lower than that (9.2%) of the women in the control group (P=0.023). Conclusion: Baofukang suppository combined with xinfuning for treating the women with HPV infection can regulate their immune function and reduce their inflammation reaction, which has significant curative effect, good safety of medication, and low recurrence rate, and which mechanism may be related to the regulation of immunity and the reduction of inflammatory response
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