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| Analysis of high-risk papilloma virus infection situation and related risk factors of pregnant women during the third trimester of pregnancy |
| Haikou Maternal and Child Health Care Hospital, Hainan Province, 570203 |
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Abstract To explore the situation of high-risk human papilloma virus (HPV) infection and the related risk factors of pregnant women during the third trimester of pregnancy in Haikou area, and to analyze the related risk factors of the high-risk HPV infection. Methods: A total of 4600 pregnant women during the third trimester of pregnancy who underwent HPV screening and HPV typing test were selected in this study from January 2017 to December 2020. The epidemiological investigation of high-risk HPV infection of the pregnant women during the third trimester of pregnancy was conducted by questionnaire and clinical data analysis, and the related risk factors were analyzed. Results: Among the 4600 women who received the questionnaire, 4469 women had returned the valid questionnaires with the rate of returned successful of 97.2%. In 4469 cases, there were 434 cases with high-risk HPV infection with the infection rate of 9.71%. The highest infection rates of high-risk HPV subtypes were HPV16 and HPV52, which’s infection rates were 1.4% and 1.2%, respectively. Univariate analysis showed that age, pregnancy number, age of the first pregnancy, sexual behavior during pregnancy, sexual partner, extramarital sexual partner of husband, sexual partner, cervicitis, abnormal vaginal secretion of the pregnant women were the risk of high-risk HPV infection of the pregnant women during the third trimester of pregnancy (P<0.05), while delivery number, smoking history, drinking history, urinary tract infection and other factors were not the factors of high-risk HPV infection (P>0.05). The results of logistic stepwise regression analysis model showed that sexual behaviour during pregnancy, sexual partners, extramarital sexual partner of husband, and cervicitis were the independent risk factors of high-risk HPV infection (P<0.05). Conclusion: The prevalent dominant subtypes of high-risk HPV infection among pregnant women during the third trimester of pregnancy in Haikou area are HPV16 and HPV52. The publicity and intervention for the pregnant women can be strengthened according to the risk factors of high-risk HPV infection in Haikou area.
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