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Abstract To observe the thyroid hormone levels of normal pregnant women during different stages of pregnancy, and to establish the reference range of thyroid hormones levels of pregnant women during the first, second, and third trimester of pregnancy. Methods: 900 pregnant women were selected in study group (the standard population group). Another 200 healthy non-pregnant women were selected in control group. The levels of serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroglobulin antibody (Tg-Ab), and thyroid peroxidase antibody (TPO-Ab) were detected by chemiluminescence method, and the change characteristics of which during different pregnancy periods were analyzed. The reference value range of the thyroid hormone levels was formulated. In addition, the data of 3400 pregnant women during different pregnant stages were collected to verify the effect of the reference value range of the thyroid hormone levels for diagnosing subclinical hypothyroidism of the pregnant women. Results: There were significant different in the levels of FT3, FT4 and TSH of the women before pregnancy between the two groups (P<0.05). The levels of FT3 and FT4 of the women in the study group decreased gradually with the increase of the gestational weeks, while the TSH level increased gradually (P<0.05), there were no significant differences in the TPO-Ab and Tg-Ab levels of the women between groups (P>0.05). Percentile 2.5 as the lower limit and percentile 97.5 as the upper limit, the reference values of FT3 level of the women during the first, middle, and third trimesters of pregnancy were 3.08-5.42 pmol/L, 2.89-5.23 pmol/L, and 2.48-4.82 pmol/L, respectively, the reference values of FT4 level of the women during the first, middle, and third trimesters of pregnancy were 9.32-18.21 pmol/L, 7.28-12.89 pmol/L, 6.8511.94 pmol/L, respectively, and the reference values of TSH level of the women during the first, middle, and third trimesters of pregnancy were 0.29-4.49 mIU/L, 0.533-4.88 mIU/L, 0.68-5.37 mIU/L, respectively. Conclusion: The results of this study has established the normal reference range of thyroid hormone levels for women during different pregnancy stages in plateau region, which can provide evidences for clinical screening thyroid diseases of pregnant women.
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