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Abstract To study the influence of high risk HPV infection of women during pregnancy on their pregnancy outcomes. Methods: 162 pregnant women diagnosed by HPV infection were selected in research group，and another 162 healthy pregnant women were selected in control group from January 2015 to December 2020. The pregnancy outcomes and postpartum situation of the women were compared between the two groups, and the HPV infection types and the pregnancy outcomes of the women in the research group were analyzed. Results：The high-risk HPV infection types of the women in the research group included subtypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, and 82, and the majority of them were subtype 52 (19.8%) and subtype 16 (14.8%). There was no significant difference in adverse pregnancy outcomes rate among the women with HPV 52 subtype infection, women with HPV 16 subtype infection, women with other subtypes infection, and women with ≥2 subtypes of mixed infection in the research group (P>0.05). The rates of preterm birth (8.6%) and premature rupture of membranes (12.4%) of the women in the research group were significant higher than those (2.5% and 2.5%) of the women in the control group (P<0.05). The incidences of postpartum hemorrhage and puerperal infection of the women had no significant difference between the two groups (P>0.05). Conclusion: The common HPV subtypes of the pregnant women with high risk HPV infection during pregnancy were HPV 52 and HPV 16. HPV infection can increase the incidence of adverse pregnancy outcomes and premature rupture of membranes. Therefore, it is necessary to screen and intervene HPV infection of women pre pregnancy and during pregnancy．
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