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| Effect of ketorolac tromethamine for postoperative analgesia of patients after gynecological laparoscopic surgery and its influence on their levels of serum nerve growth factor and inflammatory factors |
| 1. Xindu District Maternal & Child Health Care Hospital, Chengdu， Sichuan Province, 610500；2. Chengdu Women’s and Children’s Central Hospital |
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Abstract To explore the effect of butorphanol combined with ketorolac tromethamine for postoperative analgesia of patients after gynecological laparoscopic surgery, and to study its influence on their levels of serum nerve growth factor (NGF) and inflammatory factors. Methods: 200 patients who underwent selective gynecological laparoscopic surgery were selected as the research subjects and were divided into two groups (100 cases in each group) by random number table from July 2019 to July 2020. The pain grade I-II of the patients was assessed by the American Society of Anesthesiologists (ASA). The patients in group A were given 10mg of butorphanol alone for postoperative analgesia, and the patients in group B were given 10mg of butorphanol combined with 60mg of ketorolac tromethamine for postoperative analgesia. Visual analog pain score (VAS) and Ramsay sedation score (RSS) at different time point, the cumulative dose of butorphanol, the number of pressing analgesia pumps in 24 hours after surgery, the occurrence of adverse reactions at 24 hours after surgery, and the degree of satisfaction for analgesia of the patients in both groups were recorded. The levels of serum NGF, interleukin-6 (IL-6), IL-10, tumor necrosis factor-α (TNF-α) of the patients in both groups were also recorded. Results: The scores of VAS and RSS of the patients in group B at different time point after surgery were significant lower than that of the patients in group A, and the cumulative dosage of analgesics and the number of analgesic pump pressing within 24h after surgery of the patients in group B were significant less than those of the patients in group A. The total incidence of postoperative adverse reactions (10.0%) of the patients in group B was significant lower than that (24.0%) of the patients in group A, but the degree of satisfaction for analgesia (98.0%) of the patients in group B was significant higher than that (84.0%) of the patients in group A (all P<0.05). After operation, the levels of serum IL-6, IL-10, and TNF-α of the patients in both groups had increased significantly, but the NGF level had decreased significantly, and which changes of the patients in group B was significant better than that of the patients in group A (P<0.05). Conclusion: Butorphanol combined with ketorolac tromethamine for postoperative analgesia of the patients after gynecological laparoscopic surgery has better analgesia effect, which can reduce the dosage of analgesics drug, and can better relieve postoperative inflammation situation, reduce the impact on neurological function, and can improve satisfaction with analgesia of the patient.
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