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| Correlation between the levels of serum placenta growth factor, thyroid peroxidase antibody, and hemoglobin 1c of pregnant women with gestational diabetes mellitus and their maternal and infant outcomes |
| Liangshan Yi Autonomous Prefecture Hospital of Integrated Traditional Chinese and Western Medicine, Sichuan Province, 615000 |
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Abstract To investigate the relationship between the levels of serum placenta growth factor (PLGF), thyroid peroxidase antibody (TPOAb), and hemoglobin 1c (HbA1c) of pregnant women with gestational diabetes mellitus (GDM) and their maternal and infant outcomes. Methods: 55 pregnant women with GDM were selected in observation group, and 55 healthy pregnant women were selected in control group from January 2018 to March 2020. The serum levels of PLGF, TPOAb, and HbA1c, and the maternal and infant outcomes of the women were compared between the two groups. Logistic stepwise regression was used to analyze the relationship between the levels of serum PLGF, TPOAb, and HbA1c of the women and their adverse maternal and infant outcomes. Results: The levels of serum PLGF (58.78±10.27 pg/ml), TPOAb (46.37±8.87 U/ml), and HbA1c (5.77±1.02%) of the women in the observation group were significant lower than those of the women in the control group, but the positive rate of TPOAb (30.9%) of the women in the observation group was significant higher than that of the women in the control group (all P<0.05). The incidence of adverse maternal and infant outcomes (25.5%) of the women in the observation group was significant higher than that (9.1%) of the women in the control group (P<0.05). The serum PLGF level of pregnant women with adverse maternal and infant outcomes was significant lower than that of normal pregnant women, but the serum TPOAb and HbA1c levels and the positive rate of TPOAb of pregnant women with adverse maternal and infant outcomes were significant higher (P<0.05). The decrease of PLGF level and the increase of TPOAb and HbA1c levels were the risk factors of adverse maternal and infant outcomes of pregnant women with GDM (P<0.05). Conclusion: The serum levels of TPOAb and HbA1c of pregnant women with GDM are significant higher than those of healthy women, but their serum level of PLGF was significant lower. The serum levels of PLGF, TPOAb, and HbA1c of pregnant women with GDM are significantly correlated with their adverse maternal and infant outcomes.
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