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| The change characteristics of the vaginal microecological environment of postmenopausal women with high risk-human papilloma virus infection |
| The First People's Hospital of Wuyi, Jinhua, Zhejiang Province, 321200 |
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Abstract To analyze the characteristics of the vaginal microecological environment of postmenopausal women with high risk-human papilloma virus (HR-HPV) infection. Methods: From January 2017 to December 2019, the postmenopausal women with HR-HPV infection were selected in group A, the child-bearing period women with HR-HPV infection were selected in group B, and the postmenopausal women without HR-HPV infection were selected in group C. The changes of the indexes on vaginal microecological morphology and functionality of the women in the three groups were analyzed according to their biopsy pathology and HPV infection types. Results: The rates of PH value ≥5.0, vaginal cleanliness III-IV, and the positive ratios of BV, H2O2, SNA, and GUS of the women in group A were significant higher than those of the women in group C, but those of the women in group C were significant lower than those of the women in group B (all P＜0.05). The positive ratios of VVC, TV, LE, and NAG of the women in group A were significant lower than those of the women in group B (P＜0.05), but there were no significant differences in the positive ratios of VVC, TV, LE, and NAG of the women between group B and group C (P＞0.05). The ratios of PH≥5.0, vaginal cleanliness III-IV, BV, positive H2O2, and positive SNA of the women with biopsy pathology ≥HSIL were significant higher than those of the women with biopsy pathology <LSIL (P＜0.05), but there were no significant differences in the positive ratios of VVC, TV, LE, NAG, and GUS between the women with biopsy pathology ≥HSIL and the women with biopsy pathology <LSIL (P＞0.05). The ratios of PH≥5.0, vaginal cleanliness III-IV, BV, positive H2O2, positive SNA, and positive GUS of the women with multiple HPV infections were significant higher than those of the women with single HPV infection (P＜0.05), but there were no significant differences in the positive ratios of VVC, TV, LE, and NAG between the women with multiple HPV infections and the women with single HPV infection (P＞0.05). Positive BV, H2O2, and SNA were the independent risk factors of the multiple HPV infections of postmenopausal women (P＜0.05). Conclusion: The characteristics of vaginal microecology of the postmenopausal women with HR-HPV infection are different from those women of childbearing age, which may lead to their high-grade cervical lesions and multiple HPV infections.
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