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| Effect of iodine nutrition combined with thyroid hormone replacement therapy for pregnant women with subclinical hypothyroidism and its pregnancy outcomes |
| Haikou Hospital Affliated to Xiangya School of Medicine of Central South University, Haikou, Hainan Province, 570203 |
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Abstract To analyze the effect of iodine nutrition combined with thyroid hormone replacement therapy for pregnant women with subclinical hypothyroidism. Methods: 150 pregnant women with subclinical hypothyroidism were selected and divided into two groups according to the number random table method from January 2018 to March 2020. 75 women in control group were given iodine nutrition, and 75 women in observation group were given iodine nutrition combined with thyroid hormone replacement therapy. The changes of thyroid function indexes levels and pregnancy outcomes of the women were compared between the two groups. Results: During 32 gestational weeks, the level of serum free thyroxine 4 (FT4) (9.80±2.63 pmol/L) of the women in the observation group was significant higher than that (8.10±2.49 pmol/L) of the women in the control group, and the level of thyroid stimulating hormone (TSH) (1.50±0.51 mIU/L) of the women in the observation group was significant lower than that (2.01±0.49 mIU/L) of the women in the control group. The variation coefficients of the values of 24h SBP (11.05± 1.24mmHg) and 24h DBP (6.24± 1.15mmHg) of the women in the observation group were significant lower than those (13.46± 1.36mmHg and 7.36± 1.20mmHg) of the women in the control group. The incidence of adverse pregnancy outcomes (4.0%) of the women in the observation group was significant lower that (13.3%) of the women in the control group (all P＜0.05). There was no significant difference in the incidence of adverse outcomes (1.3% vs. 4.0%) of perinatal infants between the two groups (P＞0.05). During the treatment period, the women in both groups were able to tolerate. 1 woman (1.3%) in the observation group had palpitation discomfort at the beginning of treatment, and which symptoms had disappeared after increasing the dosage of FT4, and then had no any discomfort after gradually increased the dosage of FT4. All the women in the control group had completed the treatment without any palpitation and other discomfort. Conclusion: Iodine nutrition combined with thyroid hormone replacement therapy for pregnant women with subclinical hypothyroidism can significantly improve their thyroid function, which can reduce the occurrence of adverse pregnancy outcomes with higher safety.
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