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| Prevention of recurrence after hysteroscopic endometrial polyp excision by Xuefuzhuyu capsule combined with drospirenone ethinylestradiol tablets |
| The Second Affiliated Hospital of Luohe Medical College, Henan Province, 462000 |
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Abstract To investigate the effect of Xuefuzhuyu capsule combined with drospirenone ethinylestradiol tablets for preventing endometrial polyp (EP) recurrence of women after hysteroscopic endometrial polyp excision. Methods: The women with EP after hysteroscopy endometrial polyps excision were selected as the study objects from February 2016 to October 2018. These women were divided into observation group and control group according to the principle of random number. The women in the observation group were treated with Xuefuzhuyu capsule combined with drospirenone ethinylestradiol tablets, and the women in the control group were treated with drospirenone ethinylestradiol tablet. The endometrial thickness, menstrual volume, complications rate, and EP recurrence rate in 6 months, 12 months and 18 months of the women after operation were compared between the two groups. Results: The endometrial thickness and PBAC score in 6, 12 and 18 months after operation of the women in the two groups had decreased significantly, and which of the women in the observation group were significant lower than those of the women in the control group (all P＜0.05). There were no significant differences in the incidences of gastrointestinal reactions and irregular vaginal bleeding of the women between the two groups (P＞0.05). There was no significant difference in the recurrence rate of EP (1.1% vs.0.0%) of the women in 6 months after operation between the two groups (P＞0.05), but which (3.1% and 7.3%) of the women in the observation group in 12 and 18 months after operation were significant lower than those (11.7% and 19.2%) of the women in the control group (P＜0.05). There was no significant difference in the rate of the women with the average diameter of maximum polyps ≥2.0cm in 6 months after surgery between the two groups (P＞0.05), but which (2.0% and 4.1%) of the women in the observation group in 12 and 18 months after operation were significant lower than those (15.4% and 23.1%) of the women in the control group (P＜0.05). There was no significant difference in the rate of the women with the average diameter of maximum polyps <2.0cm in 6, 12, and 18 months after operation between the two groups (P＞0.05). There was no significant difference in the rate of the women with the number of polyps ≥3 in 6 months after operation between the two groups (P＞0.05), but which (4.3% and 4.3%) of the women in the observation group in 12 and 18 months after operation were significant lower than those (19.1% and 23.8%) of the women in the control group (P＜0.05). There was no significant difference in the rate of the women with the number of polyps <3 in 6, 12, and 18 months after operation between the two groups (P＞0.05). Conclusion: The efficacy of Xuefuzhuyu capsule combined with drospirenone ethinylestradiol tablets for preventing EP recurrence after hysteroscopy endometrial polyps excision is superior to that of drospirenone ethinylestradiol tablets used alone, especially for the women with large or multiple polyps.
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