|
Abstract To explore the value of three-dimensional ultrasound combined with pregnancy associated plasma protein A (PAPP-A) level for diagnosing placental implantation. Methods: From December 2015 to December 2018, 400 pregnant women who underwent cesarean section were selected as the study objects. According to the analysis of pathological results after delivery, they were divided into 254 women with placenta implantation in group A and 146 women without placenta implantation in group B. All these women were examined by prenatal three-dimensional (3D) ultrasonography, and the levels of serum PAPP-A and vascular endothelial growth factor (VEGF) of these women were measured before delivery. Based on the pathological results after delivery as the "gold standard", the diagnostic value of 3D ultrasonography, the serum PAPP-A level, or the combination of 3D ultrasonography and serum PAPP-A level for placenta implantation was compared. Results: The serum PAPP-A level (685.69±201.47g/L) of the women in group A was significant lower than that (896.37±245.26g/L) of the women in group B, but the serum VEGF level (342.62±37.84 pg/ml) of the women in group A was significant higher than that (278.41±34.19 pg/ml) of the women in group B (P＜0.05). The sensitivity of 3D ultrasonography, serum PAPP-A level, and the combination of 3D ultrasonography and serum PAPP-A level for diagnosing placental implantation were 82.7%, 88.9%, and 89.4%, respectively. The specificity of 3D ultrasonography, serum PAPP-A level, and the combination of 3D ultrasonography and serum PAPP-A level for diagnosing placental implantation were 84.3%, 81.5%, and 89.0%, respectively. The diagnostic accuracy of 3D ultrasonography, serum PAPP-A level, and the combination of 3D ultrasonography and serum PAPP-A level for diagnosing placental implantation were 83.3%, 81.8%, and 89.3%, respectively. Conclusion: The combination of 3D ultrasonography and serum PAPP-A level for diagnosing placental implantation can significantly improve the sensitivity and the accuracy, which has higher clinical diagnostic value.
|
|
|
|
|
|
