To study the anesthesia effect of ultrasound-guided transverse plane block combined with general anesthesia in cesarean section due to placenta previa. Methods: 97 women with placenta previa who received cesarean section from January 1, 2018 to January 1, 2020 were collected retrospectively. According to the different anesthesia methods, these women were divided into group A (women with general anesthesia), group B (women with intraspinal anesthesia), and group C (women with nerve block combined general anesthesia). The basic information, prenatal bleeding volume, anesthesia method, and postoperative pain situation of the women were analyzed and compared among the three groups. Results: The average blood transfusion volume and self blood transfusion volume of the women in group A were the highest, and those of the women in group B were the lowest (P＜0.05), but those of the women had no significant difference between group C and group A (P＞0.05). The proportion of Apgar score < 7 of newborns within 1 min after born in group A was the highest (P＜0.05). The duration of mechanical ventilation of the women in group C was the shortest, and the consumption of remifentanil of the women in group C was the lowest. The hospitalization time of the women in group A was the longest (P＜0.05). In resting or active state, the pain score at postoperative 12h-48h of the women in group A was the highest (P＜0.05), while that at postoperative 48h of the women in group C was significant lower (P＜0.05). Conclusion: During cesarean section of women with placenta previa, general anesthesia may increase the amount of blood loss, influence on neonatal respiration, and has less postoperative analgesia effect. Ultrasound-guided lower abdominal transverse plane block combined with general anesthesia can reduce the amount of bleeding amount, reduce the adverse influence on neonatal respiration, and improve postoperative analgesia.