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| Expression and predictive value of HIF-1α, β-hCG, and progesterone levels of women with recurrent spontaneous abortion during the first trimester of pregnancy |
| 1. Kunming Angel Obstetrics and Gynecology Hospital; 2. The Second Affiliated Hospital of Kunming Medical University; 3. The Second Affiliated Hospital of Yunnan University of Chinese Medicine |
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Abstract To investigate the expression and predictive value of hypoxia-inducible factor-1α (HIF-1α), β-human chorionic gonadotropin (β-hCG), and progesterone (P) of women with recurrent spontaneous abortion (RSA) during the first trimester of pregnancy. Methods: 102 pregnant women during the first trimester of pregnancy from June 20 to June 2019 were retrospectively selected, and were divided into three groups according to their pregnancy outcomes, which included group A (46 women with normal pregnancy), group B (35 women with abortion), and group C (21 women with RSA). The levels of serum HIF-1α, β-hCG, and P of the women during 6, 7, and 8 gestational weeks in the three groups had been detected. Correlation of serum levels of HIF-1α, β-hCG, and P of women in group C was analyzed by Pearson correlation analysis. The predictive value of serum HIF-1α, β-hCG, and P levels for predicting RSA during the first trimester of pregnancy was analyzed by receiver operating characteristic (ROC) curve. Results: During 6, 7, and 8 gestational weeks, the serum HIF-1α level of the women in group C was the highest, followed by that of the women in group B, and that of the women in group A was the lowest. During 6, 7, and 8 gestational weeks, the serum β-HCG level or P level of the women in group C was the lowest, followed by that of the women in group B, and that of the women in group A was the highest (all P＜0.05). There was a negative correlation between serum HIF-1αlevel and β-HCG level of the women in group C (P＜0.05), and the serum HIF1αlevel and β-HCG level of the women in group C had no correlation with their serum P level (P＞0.05). The predictive value of combinational detection of serum HIF-1α, β-HCG, and P levels during the first trimester of pregnancy for RSA was significant better than that of serum HIF-1αlevel, β-HCG level, or P level alone (P＜0.05). Conclusion: The serum HIF-1α of the women with RSA during the first trimester of pregnancy expresses highly, while their serum β-HCG and P levels express lowly. The combinational detection of serum HIF-1α, β-HCG, and P levels during the first trimester of pregnancy for predicting RSA has higher value.
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