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| Analysis of the high risk factors of tumor cell metastasis of the patients with endometrioid adenocarcinoma |
| Fuyang Hospital, Anhui Medical University, Fuyang, Anhui Province, 236000 |
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Abstract To explore the high risk factors of tumor cell metastasis of the patients with endometrioid adenocarcinoma (EA). Methods: From August 2017 to October 2020, 108 patients with EA were selected as research objects, and they were divided into 19 patients with tumor cell metastasis and 89 patients without tumor cell metastasis according to whether the patients had tumor cell metastasis in vitro. The age, menopause status, histological grade, estrogen receptor, myometrial invasion depth, tumor size, the levels of tumor protein p53 and cancer antigen 125, the values of peripheral blood neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), and other clinical data were collected and statistically analyzed. The relationship between tumor cell metastasis and clinical features of EA was analyzed. Multivariate Logistic regression was used to analyze the high risk factors of cell migration of EA. Results: There were no significant different in the cell migration rate of EA among the patients with different age, with different menopause status, with different tumor size, or with different tumor antigen 125 level (P＞0.05). but there were significant different in the cell migration rate of EA among the patients with different histological grade, with different estrogen receptor level, with different myometrial invasion depth, with different tumor protein p53 level, or with different values of peripheral blood NLR and PLR (P＜0.05). Multivariate Logistic regression analysis showed that estrogen receptor level, and the values of peripheral blood NLR and PLR were independent risk factors of cell migration of EA (P＜0.05). Conclusion: The independent risk factors of tumor cell metastasis of EA are estrogen receptor level, and the values of NLR and PLR.
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