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| Relationship between miR-122-5p level and clinicopathological features in patients with epithelial ovarian cancer and its value for predicting the postoperative prognosis |
| Taikang Xianlin Drum Tower Hospital, Nanjing, Jiangsu Province, 210046 |
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Abstract To investigate the relationship between miR-122-5p level of patients and their clinicopathological features of epithelial ovarian cancer (EOC), and to study its value for predicting the postoperative prognosis of the patients. Methods: 118 patients with EOC underwent surgery were selected as research subject during August 2014 and August 2017, and the expression level of miR-122-5p in tumor tissues and adjacent tissues of the patients was compared. According to the situation of postoperative followed up, the patients were divided into group A1 (49 death patients) and group A2 (69 survival patients), and the expression differences of miR-122-5p in tumor tissues of the patients were compared between the two groups, and the value of miR-122-5p level for predicting postoperative survival of the patients with EOC was analyzed by receiver operating characteristic (ROC) curve. According to the optimal cutoff value of ROC curve, the patients with EOC were divided into group B1 (64 patients with high expression of miR-122-5p) and group B2 (54 patients with low expression of miR-122-5p), and the survival differences of the patients was compare between group B1 and B2. The clinicopathological characteristics of the patients with different miR-122-5p expression were analyzed, and the influencing factors of postoperative survival outcomes were analyzed by multivariate Cox regression model. Results: The miR-122-5p level in tumor tissues (0.31±0.08) was significant lower than that (0.40±0.11) in adjacent normal tissues. The level of miR-122-5p in tumor tissues of the patients in group A1 (0.26±0.06) was significant lower than that (0.34±0.11) of the patients in group A2 (P＜0.05). ROC curve showed that the optimal cutoff value of miR-122-5p expression level in tumor tissue of the patients for predicting postoperative death rate during the followed up period was 0.30, and the AUC was 0.808 (95%CI,0.7388-0.891), with the sensitivity of 68.1% and the specificity of 75.5%. Kaplan-Meier survival curve showed that the postoperative survival outcomes of the patients in group B1 was significant better than that of the patients in group B2 (P＜0.05). Cox regression analysis showed that miR-122-5p level ≤0.30, FIGO Ⅲ stage, and complicated lymph node metastasis were the independent risk factors of postoperative death of patients with EOC (P＜0.05). Conclusion: Expression level of miR-122-5p in tumor tissue of the patients with EOC is closely related to their clinicopathological characteristics, and the decrease or even loss of miR-122-5p expression may contribute to predict the occurrence of poor postoperative prognosis of the patients with EOC.
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