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| Relationship between the GLUT, IRS and SHBG levels in placental tissues of pregnant women and their gestational diabetes mellitus occurrence |
| 1.Tengzhou maternal and child health care hospital, Tengzhou, Shandong Province 277500；2. Zaozhuang Municipal Hospital of Shandong Province |
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Abstract To observe the expression of glucose transporter (GLUT), insulin signal transduction protein (IRS), and sex hormone binding globulin (SHBG) in placental tissues of pregnant women with gestational diabetes mellitus (GDM)，and to study the relationship between the GLUT, IRS and SHBG levels in placental tissues of pregnant women and their GDM occurrence. Methods: 42 pregnant women with GDM and cesarean section were selected in study group from December 2008 to December 2018，and 42 healthy pregnant women were selected in control group during the same period. The expression of GLUT, IRS and SHBG in placenta tissue of the women in the two groups were detected，and which’s clinical significances were analyzed. Results: The levels of fasting blood glucose and 2h blood glucose of OGTT of the women, and neonatal weight in study group were all significant higher than those of the women in the control group, but the levels of GLUT-3, GLUT-4, IRS-2, P13K p85α, and SHBG mRNA in the placenta of the women in the study group were significant lower than those of the women in the control group (all P＜0.05). Pearson analysis showed that SHBG level was positive correlated with the levels of GLUT-3, GLUT-4, IRS-2, and P13K P85α mRNA, and IRS-2 level was positive correlated with GLUT-1 and GLUT-4 mRNA levels. IRS-1 level was negative correlated with GLUT-3 and P13K P85α mRNA levels, and SHBG level was positive correlated with GLUT-3, GLUT-4, and IRS-2 protein levels, and IRS-2 level was positive correlated with GLUT-3 and GLUT-4 levels. IRS-1 level was negative correlated with GLUT-3 protein level. Conclusion: The decrease of SHBG of pregnant women with GDM leads to the disorder of sex hormone metabolism and decrease of glucose metabolism, and further leads to insulin resistance. When the SHBG level of pregnant women with GDM has reduced, the related molecular levels of insulin signal transduction pathway also change, thus reduce the uptake and utilization of glucose in the placenta, and cause GDM occurrence eventually.
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