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Abstract To analyze the changes of ultrasonic parameters of renal blood flow of pregnant women with different severity of preeclampsia (PE), and to study its correlation with their serum oxidative stress indicator. Methods: 77 pregnant women with PE were selected and divided into group A (49 women without severe PE) and group B (28 women with severe PE) from January 2017 to December 2019. The renal artery resistance index (RI), pulse index (PI), peak systolic velocity/peak end-diastolic velocity (S/D), renal vascular index (VI), blood flow index (FI), and blood vessel flow index (VFI) of the women in the two groups were detected by two-dimensional and three-dimensional energy Doppler ultrasound. Serum levels of malondialdehyde (MDA), advanced protein oxidation products (AOPPs), lipid hydrogen peroxide (LHP) and total antioxidant capacity (T-AOC) of the women were detected by ELISA and were compared between the two groups. The correlation between ultrasonic parameters of renal blood flow and the levels of serum oxidative stress indicators was analyzed. Results: The values of RI, PI and S/D of renal artery of the women in group B were significant higher than those of the women in group A, while the values of VI, FI and VFI of the women in group B were significant lower (all P＜0.05). The serum MDA, AOPPs and LHP levels of the women in group B were significant higher than those of the women in group A, but the serum T-AOC level of the women in group B was significant lower (all P＜0.05). The serum levels of MDA, AOPPs and LHP were positive correlated with the RI value of renal artery (P＜0.001), and the T-AOC level was negative correlated with the RI value of renal artery (P＜0.05). The level of AOPPs was positive correlated with the PI value of renal artery (P＜0.05), and the T-AOC level was negative correlated with the S/D value of renal artery (P＜0.05). The MDA and LHP levels was no correlation with the values of RI and S/D of renal artery, and the serum T-AOC level was no correlation with PI value of renal artery (all P＞0.05). The serum MDA, AOPPs and LHP levels were negative correlated with the FI and VFI values of renal artery, while the T-AOC level was positive correlated with the FI and VFI values of renal artery (all P＜0.05). There was a negative correlation between the AOPPs level and the VI value of renal artery (P＜0.05), but there was no correlation between the levels of MDA, LHP and T-AOC and the VI value of renal artery (all P＞0.05). Conclusion: The abnormal oxidative stress indicator of the pregnant women with PE is related to the decrease of their renal blood perfusion, which is expected to be a reference index for evaluating their renal injury.
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