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Abstract To investigate the expression of miR-206 in placental tissues of the women with preeclampsia (PE), and to study it’s relevant to the prognosis of the women. Methods: 90 women with PE from January 2018 to December 2019 were selected in study group, and were divided into group A1 (13 women with poor prognosis), group A2 (77 women with good prognosis) according to the postpartum adverse outcomes of the women. 100 healthy pregnant women were selected in control group during the same period. The difference of miR-206 expression level in placental tissues of the women was compared between the study group and the control group. According to the median expression level of miR-206 in placental tissues of the women in the study group, the women were divided into group B1 (43 women with high miR-206 level) and group B2 (45 women with low miR-206 level), and the postpartum adverse outcomes of the women were compared between group B1 and B2. The risk factor of poor prognosis of the women with PE was analyzed. Results: The expression level of miR-206 in the placental tissue (0.61±0.09) of the women in the study group was significant higher than that (0.42±0.08) of the women in the control group, and the total incidence of postpartum adverse pregnancy outcomes (22.2%) of the women in group B1 was significant higher than that (6.7%) of the women in group B2 (all P＜0.05). Logistics regression analysis showed that age ≥30 years old, higher levels of triglyceride, creatinine and uric acid at 24h before delivery, and higher expression level of miR-206 in placental tissue of the women with PE were independent risk factors for their adverse delivery prognosis (P＜0.05). Conclusion: The expression of miR-206 in placental tissues of women with PE increases abnormally, and which is their independent risk factor for the occurrence of adverse prognosis.
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