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| Clinical effect of loop electrosurgical excision procedure for treating women with cervical intraepithelial neoplasia who wanted fertility preserving and its effect on their pregnancy outcomes |
| The Second Affiliated Hospital of Chengdu Medical College, National Nuclear Corporation 416 Hospital of China, Chengdu, Sichuan Province, 610051 |
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Abstract AbstractObjective: To analyze the clinical effect of loop electrosurgical excision procedure (LEEP) for treating women with cervical intraepithelial neoplasia (CIN) who wanted fertility preserving, and to study its effect on their pregnancy outcomes. Method: The clinical data of 200 women with CIN from January 2017 to January 2018 were analyzed retrospectively. These women were divided into group A (97 women with 15-20mm depth of LEEP resection) and group B (103 women with 21-25mm depth of LEEP resection). During the same time, 98 healthy women were selected in group C. The rates of postoperative cervical healing, cervical stenosis, and complication, and quality of life of the women were compared among the three groups. Results: The rate of complete cervical healing (88.7%) of the women in group A was significant higher than that (71.8%) of the women in group B, the rate of severe cervical stenosis (5.2%) of the women in group A was significant lower than that (22.3%) of the women in group B, and the incidence of complication (10.3%) of the women in group A was significant lower than that (32.0%) of the women in group B. The postoperative quality of life, health status, and the scores of physiological, psychological and social relationship scores of the women in group A were significant higher than those of the women in group B (all P＜0.05). There were no significant differences in the gestational weeks when delivery, birth weight of newborn, the rates of fetal distress, abnormal amniotic fluid volume, placenta previa, cervical laceration, and low birth weight, and so on of the women among the three groups (P＞0.05). The amniotic fluid volume of the women in group A and B had no significant different (P＞0.05), but the rates of preterm premature (26.1% and 24.3%), the rupture of membranes (30.4% and 21.6%), and the cesarean section rate (8.7% and 8.1%) of the women in group A and B were significant higher than those (3.0%, 3.0%, and 6.1%) of the women in group C (P＜0.05). Conclusion: LEEP treatment can increase the incidences of premature delivery, premature rupture of membranes, and cesarean section of the women with CIN who wanting fertility function reserve. When the resection depth is 15-20mm, it is more conducive to cervical repair and the quality of life improvement with higher safety. It is feasible to carry out LEEP under controlling the depth of resection strictly.
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