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| The application value of endometrial thickness measured by ultrasound, combined with the detections of estradiol and pregnancy-associated protein A for diagnosing early ectopic pregnancy |
| The First Affiliated Hospital Of Xinjiang Medical University , Urumqi, Xinjiang, 830054 |
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Abstract To explore value of endometrial thickness measured by ultrasound, combined with the detections of estradiol (E2) and pregnancy-associated protein A (PAPP-A) for diagnosing early ectopic pregnancy. Methods: 186 patients with suspected ectopic pregnancy were selected. Among them, 64 patients with diagnosed ectopic pregnancy by pathology or surgical examination were included in observation group and the other 122 patients were included in control group. The difference of the endometrial thickness measured by ultrasound and the levels of E2 and PAPP-A of the women were compared between the two groups. The value of endometrial thickness, E2 level, PAPP-A level, and the combination of endometrial thickness and the levels of E2 and PAPP-A for diagnosing early ectopic pregnancy were assessed. Results: When endometrial thickness was 9.33mm, Youden index was the highest, and the sensitivity, the specificity, and area under ROC curve for diagnosing early ectopic pregnancy were 76.6%, 74.6%, and 0.723. When E2 level was 1985.43 pmol/L, Youden index was the highest, and the sensitivity, the specificity, and area under ROC curve for diagnosing early ectopic pregnancy were 65.6%, 79.5%, and 0.75. When PAPP-A was 21.33mIU/L, the Youden index was the highest, and the sensitivity, the specificity, and area under ROC curve the combination of endometrial thickness and the levels of E2 and PAPP-A for diagnosing early ectopic pregnancy were were 100.0%, 77.0%, and 0.864. When endometrial thickness ≤9.33mm, E2 level ≤1985.43 pmol/L, and PAPP-A level ≤21.33mU/L, the sensitivity, specificity, and area under ROC curve of the combination of endometrial thickness and the levels of E2 and PAPP-A for diagnosing early ectopic pregnancy were 92.20%, 82.8%, and 0.922. Conclusion: The combination of endometrial thickness measured by ultrasound and the levels of E2 and PAPP-A for diagnosing early ectopic pregnancy can improve the diagnostic value.
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