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Abstract To explore the effect of sequential treatment of estradiol valerate combined with medroxyprogesterone in the recovery of women with multiple induced abortions. Methods: 167 women with multiple induced abortions were included and were divided into observation group and control group between July 2018 and July 2019. After abortion, 83 women in the control group were treated with conventional therapy, such as antiphlogosis and promoting uterine contraction, and 84 women in the observation group were treated with estradiol valerate combined with medroxyprogesterone except to the conventional therapy. After treatment, the postoperative vaginal bleeding time, uterine adhesion incidence, endometrial thickness, menstrual recovery time, and the uterine hemodynamic indicators, such as resistance index (RI), pulsatility index (PI), the ratio of the end-systolic peak, and the end-diastolic peak blood flow of the intimal spiral artery (S/D) of the women were compared between the two groups. Results: The incidence of intrauterine adhesions (13.1%) of the women in the observation group was significant lower than that (33.7%) of the women in the control group, and the postoperative vaginal bleeding time (6.2±1.3d) and menstrual recovery time (31.2±3.4d) of the women in the observation group were significant shorter than those (7.9±1.3d and 36.9±3.8 d) of the women in the control group (P＜0.05). The endometrial thickness (8.74±0.98mm) of the women in the observation group was significant greater than that (7.18±1.04mm) of the women in the control group, but the values of RI, PI and S/D of the women in the observation group were significant lower. The complication rate (16.7%) of the women in the observation group was significant lower than that (41.0%) of the women in the control group (P＜0.05). Conclusion: Sequential treatment by estradiol valerate combined with medroxyprogesterone for women with multiple induced abortions has better effect, which can promote the recovery of their uterine physiological function, improve their uterine blood supply and endometrial recovery.
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