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| Effects of ursodeoxycholic acid and adenosylmethionine succinate combined with polyene phosphatidylcholine for treating pregnant women with intrahepatic cholestasis |
| Sichuan Maternal and Child Health Hospital, Chengdu, Sichuan Province, 610000 |
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Abstract To investigate the effect of ursodeoxycholic acid and adenosylmethionine succinate combined with polyene phosphatidylcholine for treating pregnant women with intrahepatic cholestasis (ICP), and to study its influence on the pregnancy outcomes, bile acid level, and liver enzymes levels of these women. Methods: 120 pregnant women with ICP were selected and were randomly divided into two groups (60 cases in each group) from June 2018 to December 2019. The women in the control group were given oral ursodeoxycholic acid and adenosylmethionine succinate intravenous dripped, and the women in the experimental group were given polyene phosphatidylcholine intravenous dripped except to the treatment of the women in the control group. After 1 weeks of treatment, the bile acid level, liver enzyme level, adverse reaction rate, and pregnancy outcomes of the women in the two groups were observed. Results: After treatment, the pruritus scores of the women in both groups had decreased significantly, and which (1.29±0.11 points) of the women in the experimental group was significant lower than that (2.70±0.43 points) of the women in the control group. The levels of total bile acid, ALT, AST, TB and CG of the women in both groups had decreased significantly, and which (12.09±2.14umol/L, 67.93±30.25U/L, 73.49±21.37U /L, 11.29±4.32umol /L, and 621.20± 73.29ug/L) of the women in the experimental group were significant lower than those of the women in the control group (all P<0.001). The rates of cesarean section (15.0%), premature delivery (10.0%), amniotic fluid staining (1.7%), and fetal distress (11.7%) of the women in the experimental group were significant lower than those of the women in the control group (P<0.05).There was no any woman with adverse reaction during treatment in the two groups. Conclusion: Ursodeoxycholic acid and adenosylmethionine succinate combined with polyene phosphatidylcholine for treating pregnant women with ICP can effectively relieve the ICP symptoms, reduce their levels of bile acid and liver enzymes, and improve their pregnancy outcomes.
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