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| Relationship between the levels of glycated albumin and glycosylated hemoglobin in pregnant with gestational diabetes mellitus and their neonatal weight |
| 1. Chaoyang District Maternal and Child Health Hospital, Beijing, 100021；2. Beijing Tiantan Hospital |
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Abstract To investigate the relationship between the levels of glycated hemoglobin (HbA1c) and glycosylated albumin (GA) of pregnant women with gestational diabetes mellitus (GDM) and their neonatal weight. Methods: From January 20 to December 2018, 131 pregnant women with GDM were selected in study group, and 89 healthy pregnant women with normal blood glucose level were selected in control group. The level of HbA1c was detected by high performance liquid chromatography, and the level of GA was detected by enzymatic method. Pearson correlation analysis was used to evaluate the relationship between the levels of HbA1c and GA of the women with GDM and their neonatal birth weight, and the receiver operating characteristic (ROC) curve was used to analyze the optimal threshold value of HbAlc for predicting macrosomia. Results: The levels of HbA1c and GA of the women, the neonatal birth weight, and the proportion of macrosomia in the study group were significant higher than those in the control group (P<0.05). Pearson correlation analysis showed that the birth weight of newborn was positively correlated with the HbA1c level of the women (r=0.342, P<0.05), but the birth weight of newborn had no correlation with the GA level of the women (r=0.045, P>0.05). The incidence of macrosomia (12.5%) of women with low HbA1c level was the lowest, followed by the women with moderate HbA1c level (14.3%), and that (29.2%) of the women with high HbA1c level was the highest (P<0.05). In the study group, the area under the ROC curve (AUC) and 95%CI of the HbA1c level for diagnosing macrosomia were 0.684 and 0.554-0.767, respectively. And when the cutoff point was 6.3%, the diagnostic sensitivity and the specificity of the HbA1c level for diagnosing macrosomia were 75.9% and 60.3%, respectively. Conclusion: The level of HbA1c of pregnant women with GDM is related to the neonatal weight.The higher the HbA1c level, the higher the probability of having macrosomia. The level of HbA1c has guiding significance for predicting macrosomia.
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