|
|
|
| Analysis of insulin resistance and blood lipid level of the second birth pregnant women with the history gestational diabetes mellitus |
| 1. Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Jiangsu Province, 215156; 2. The First Affiliated Hospital of Soochow University; 3. Department of Basic Medicine, Yangzhou University |
|
|
|
|
Abstract To analyze and compare the differences of insulin resistance and blood lipid level of the second birth pregnant women with the history gestational diabetes mellitus (GDM). Methods: The second birth pregnant women who had undergone the first 75 g oral glucose tolerance test (OGTT) were selected as subjects from February 2017 to February 2019, which included 72 women with history GDM in observation group and another 75 women without history GDM in control group. The age, gestational weeks when OGTT, and body mass index (BMI) before and after pregnancy of these women were recorded. The levels of fasting blood glucose (FPG), fasting insulin (FINS), the 1hPG, 2hPG, 1hINS, and 2hINS after taking glucose of these women were measured. The insulin resistance (IR) index (HOMA-IR) of these women was calculated, and their levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triacylglycerol (TG) were detected. Pearson analysis was used to analyze the correlation between the blood lipid level of the women in the observation group and their other clinical indicators, and binary Logistic regression was used to analyze the influencing factors of insulin resistance. Results: There were no significant differences in age, gestational weeks, the values of pre-pregnancy and post-pregnancy BMI of the women between the two groups (P>0.05). Compared with those of the women in the control group, the levels of FPG, 1HPG, 2HPG, FINS, 1HINS, 2HINS, HOMA-IR and TCH of the women in the observation group were significant higher, while the level of HDL-C was significant lower (all P<0.05). There were no significant differences in 1HPG, 1HINS, TG, and LDL-C levels of the women between the two groups (P>0.05). Pearson correlation analysis showed that TG level of the women in the observation group was positively correlated with their levels of FPG, 2HPG, FINS, 2HINS, and HOMA-IR (P<0.05), but HDL-C level of the women in the observation group was negatively correlated with their FPG, 2HPG, FINS, 2HINS and HOMA-IR levels (P<0.05). High level of TG and low level of HDL-C were risk factors of HOMA-IR of the women (P<0.05). Conclusion: The dyslipidemia and IR rate of the second birth pregnant women with history GDM are significant higher than those of the pregnant women without history GDM, which mainly is the high TG level and low HDL-C level, and their IR are closely related to the dyslipidemia.
|
|
|
|
|
|
|
|
|
