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| Relationship between serum CXCL13 level of women and their clinical outcomes after radical resection of cervical cancer |
| Zhuji City People's Hospital, Zhejiang Province, 311800 |
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Abstract To investigate the relationship between serum CXCL13 level of women and their clinical outcomes after radical resection of cervical cancer. Methods: Between August 2013 and August 2015, 162 women with primary cervical cancer who underwent radical resection were selected in study group, and 150 healthy women were selected in control group during the same period. The difference of serum CXCL13 level of the women in the study group was compared between 24 hours before and 24 hours after the operation. According to the recurrence and metastasis status during the followed up, the women in the study were further divided into group A (69 cases with recurrence and metastasis) and group B (93 cases without recurrence and metastasis). The difference of serum CXCL13 level before and after the operation of the women was compared between group A and B, and the value of serum CXCL13 level of the women for predicting the recurrence and metastasis after radical resection of cervical cancer were analyzed. Logistic regression was used to analyze the risk factors of postoperative recurrence and metastasis of the women after radical resection of cervical cancer, and Kaplan-Meier survival curve was used to analyze the time of diseasefree survival of the women with different serum CXCL13 levels in the study group. Results: The serum CXCL13 level (185.32±30.17pg/ml) of the women in the study group 24h before surgery was significant higher than that (131.04±22.63pg/ml) of the women 24h after surgery, and which was also significant higher than that (115.84±23.19pg/ml) of the women in the control group (all P<0.05). There was no significant difference in the serum CXCL13 level of the women 24h before surgery between group A and group B (P> 0.05), but and the serum CXCL13 level 24h after surgery of the women in group A was significant higher than that of the women in group B (P<0.05). ROC curve showed that the optimal cutoff value of serum CXCL13 level 24h after radical resection of cervical cancer for predicting recurrence and metastasis of the women in the study group was 132.70pg/ml, and which’s AUC, sensitivity, and specificity were 0.886 (95%CI 0.838-0.934), 74.2%, and 87.0%, respectively. Logistics regression analysis showed that the women with FIGO clinical stage Ⅱ, poorly differentiated cancer, cervical infiltration depth > 1/2, infiltration the side of uterus, lymph node metastasis, and the serum level of CXCL13 postoperative 24 h ≥132.70 pg/ml were independent risk factors of the recurrence and metastasis after radical resection of cervical cancer (P<0.05). Kaplan-Meier survival curve showed that the disease-free survival time of the women with low CXCL13 level after radical resection of cervical cancer was longer than that of the women with high CXCL13 level (P<0.05). Conclusion: Higher postoperative CXCL13 level of the women with radical resection of cervical cancer early is an independent risk factor for the recurrence and metastasis of cancer during long-term followed up, which maybe a factor affecting the disease-free survival time of the women.
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