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| Analysis of the infection and drug susceptibility test of chlamydia trachomatis and ureaplasma urealyticum in genital tract of infertility women |
| Qinghai Maternal and Child Health Care Hospital, Xining, Qinghai Province, 810000 |
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Abstract To explore the infection situation and drug susceptibility test of chlamydia trachomatis (CT) and ureaplasma urealyticum (UU) in genital tract of infertility women. Methods: 126 infertile women were selected in study group from January 2018 to December 2019, and 130 normal women were randomly selected in control group during the same period. The genital tract secretion samples of the women in the two groups were collected, and the samples were detected to analyze their infection situation of CT and UU. The positive strains were further tested for drug susceptibility test in vitro. Results: The rates of CT positive (20.6%), UU positive (45.2%), double positive of CT+UU (9.5%) and total infection rate (75.4%) of the women in the study group were significant higher than those (3.1%, 6.2%, 1.5%, and 10.8%) of the women in the control group (P<0.05). CT infection alone was sensitive to minocycline (86.7%) and to azithromycin (76.7%), but which was resistant to ciprofloxacin (76.7%) and levoxloxacin (76.7%). UU infection alone was sensitive to doxycycline (92.3%) and crossthromycin (92.3%), but which was resistant to ciprofloxacin (75.4%) and sparfloxacin (46.2%). The infection of CT and UU was sensitive to minocycline (92.9%) and azithromycin (85.8%), but which was resistant to ciprofloxacin (71.4%) and levoxloxacin (64.3%). Conclusion: The infection of genital CT and UU of the infertility women is high, and the infection situation detection has certain guiding significance for clinical diagnosis and treatment of female infertility. Based on the drug susceptibility test of bacterium, antibiotics should be selected rationally to improve the clinical efficacy.
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