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| Correlation between transforming growth factor β1 and neutrophil/lymphocyte of women with pregnancy induced hypertension and the maternal and infant prognosis |
| The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xian, Shaanxi Province, 710000 |
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Abstract To investigate the relationship between serum transforming growth factor β 1 (TGF-β1), neutrophil/lymphocyte of women with pregnancy induced hypertension (PIH) and the maternal and infant prognosis. Methods: From January 2019 to December 2019, 256 women with PIH were selected in study group, and 100 normal pregnant women were selected in control group during the same time. The levels of serum TGF-β1 and neutrophil/lymphocyte of the women were compared between the two groups, and the correlation was analyzed. Results: The levels of TGF-β1, neutrophil (Neuc), and neutrophil/lymphocyte of the women in the study group were significant higher than those of the women in the control group (P<0.05), but the lymphocyte (LymC) level had no significant difference between the two groups (P>0.05). The levels of TGF-β1, NEUC, neutrophil/ lymphocyte of the women with severe preeclampsia were the highest, followed by those of the women with mild preeclampsia, and those of the women with PIH are the lowest (P<0.05). There was no significant difference in the LymC level among the women with severe preeclampsia, the women with mild preeclampsia, and the women with PIH (P>0.05). The levels of TGF-β1 and neutrophil/lymphocyte of the women with adverse pregnancy outcomes were significant higher than those of the women without adverse pregnancy outcomes. The levels of TGF-β1 and neutrophil/lymphocyte of the women with adverse neonatal outcomes were significant higher than those of the women without adverse neonatal outcomes, and which had increased with the aggravation of adverse neonatal outcomes, such as fetal growth restriction, fetal distress, neonatal asphyxia, and fetal intrauterine death (all P<0.05). Pearson correlation analysis showed that the levels of the serum TGF-β1 and eutrophil/lymphocyte were positively correlated with the occurrence of adverse pregnancy outcomes and adverse neonatal outcomes of pregnant women with PIH (all P<0.05). The sensitivity (0.766) and the specificity (0.864) of TGF-β1 level combined with neutrophil/lymphocyte level for diagnosing PIH were significant higher than those of TGF-β1 level or neutrophil/lymphocyte level alone (all P<0.05). Conclusion: The levels of TGF-β1 and neutrophil/lymphocyte of pregnant women are closely related to their severity of PIH, which can be used as the clinical index for predicting adverse of mother and child.
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