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| The influence of thawing embryo transfer cycle and fresh embryo transfer cycle on the pregnancy outcomes of patients with polycystic ovary syndrome |
| The Fifth Hospital of Wuhan, Hubei Province, 430500 |
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Abstract To investigate the effect of thawing embryo transfer cycle and fresh embryo transfer cycle on the pregnancy outcomes of patients with polycystic ovary syndrome (PCOS). Methods: The clinical data of 651 patients with PCOS who had received assisted reproductive technology from January 2016 to January 2020 were collected retrospectively, which included 255 patients with fresh embryo transfer in group A, and 396 patients with thawing embryo transfer in group B. The followed up data of the patients in the two groups were analyzed, and the pregnancy outcomes of the patients were compared between the two groups. Results: The total dose of gonadotropin (Gn) on hCG day of the patients in group B was significant lower than that of the patients in group A, but the progesterone level, the numbers of follicles and eggs obtained of the patients in group B were significant higher than those of the patients in group A (P<0.05). There were no significant differences in the estrogen level on hCG day, and the incidences of ectopic pregnancy, spontaneous abortion, multiple pregnancy, perinatal fetal death，and birth defects of the patients between the two groups (P>0.05). The embryo implantation rate (54.0%) and clinical pregnancy rate (76.8%) of the patients in group B were significant higher than those (43.9% and 58.8%) of the patients in group A, but the incidences of premature birth (7.8%) and ovarian hyperstimulation syndrome (OHSS, 2.0%) of the patients in group B were significant lower than those (14.9% and 9.0%) of the patients in group A (P<0.05). There were 319 births in group A and 492 births in group B. The birth weight of neonates in group B was significant higher than that of neonates in group A, and the ratio of low birth weight infants in group B was significant lower than that in group A (P<0.05), but there was no significant difference in the rate of macrosomia between the two groups (P<0.05). Conclusion: Compared with those of fresh embryo transfer, the clinical pregnancy rate and live birth rate of thawing embryo transfer of patients with PCOS are higher with lower OHSS occurrence, so as to improve the pregnancy outcomes.
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