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| Effect of different adjuvant therapy after seperation of intrauterine adhesion and its influence on the postoperative pregnancy |
| Xiaogan Central Hospital, Hubei Province, 432000 |
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Abstract To investigate the influence of different adjuvant therapy for fertility women with intrauterine adhesion (IUA) after transcervical resection of adhesion (TCRA) on the postoperative pregnancy. Methods: 96 women with IUA were selected and were divided into groups A, B and C by random number table method from January 2017 to January 2008. The women in group A were treated with intrauterine device (IUD) combined with hyaluronic acid and oral estrogen and progesterone, the women in group B were treated with IUD combined with oral estrogen and progesterone, and the women in group C were treated with oral estrogen and progesterone combined with hyaluronic acid. The women in the three groups were followed up for 1 year, and the treatment effect and pregnancy success rate within 1 year after operation of the women in the three groups were observed. Results: 3 months after operation, the incidence of re-adhesion of the women in group A was the lowest (9.4%), but which had no significant different among the three groups (P>0.05). The endometrial thickness of the women in the three groups had increased significantly, and increased most was in group A (P<0.05). The effective rate (93.8%) of the women in group A was the highest, and that (71.9%) of the women in group B was the lowest, but which had no significant different among the three groups (P>0.05). There was no significant difference in adverse reactions of the women among 3 groups (P>0.05). The success rate of pregnancy within one year after operation (53.1%) of the women in group A was the highest, but which had no significant different among the three groups (P>0.05). Conclusion: After TCRA, application of IUD combined with hyaluronic acid and oral estrogen and progesterone can effectively prevent postoperative intrauterine re-adhesion, improve clinical symptoms and success rate of pregnancy within one year after operation, which has better clinical efficacy than that of IUD combined with oral estrogen and progesterone or hyaluronic acid combined with oral estrogen and progesterone.
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