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Effect of chemotherapy on vaginal microecosystem of women after endometrial cancer surgery and its relationship with vaginal stump infection |
| 1.Nanyang Central Hospital, Nanyang, Henan Province, 473000; 2. The First Affiliated Hospital of Xinxiang Medical College |
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Abstract To explore the effects of chemotherapy on the vaginal microecology of women after initial surgery of endometrial cancer, and to analyze its relationship with vaginal stump infection. Methods: The clinical data of 64 women with endometrial cancer surgical who had undergone postoperative chemotherapy (in observation group) and 64 women with endometrial cancer surgical who had not undergone postoperative chemotherapy (in control group) from January 2012 to March 2013 were retrospectively analyzed. The levels of tumor markers, such as carbohydrate antigen 125 (CA125), carbohydrate antigen 199 (CA199), the situation of vaginal microecosystem, and the rate of vaginal stump infection of women before operation and 6 months after operation were compared between the two groups. The 5-year overall survival rate and tumor-free survival rate of women in the two groups were recorded. The survival curve drawn by KaplanMeier method was used for evaluating postoperative survival situation of women in the two groups. Results: 6 months after operation, the serum levels of CA125 and CA199 had decrease significantly, and those of women in the observation group were significant lower than those of women in the control group (P＜0.05). 6 months after operation, the abnormal rate of vaginal cleanliness (28.1%), pathogen infection rate (20.3%) and incidence of vaginal stump infection (17.2%) of women in the observation group were all significant higher than those (12.5%, 7.8%, and 4.7%) of women in the control group (P＜0.05). 5 years after surgery, the overall survival rate (90.6%) and the disease-free survival rate (81.3%) of women in the observation group were both significant higher than those (76.6 % and 65.6%) of women in the control group (P＜0.05). Conclusion: Chemotherapy after initial surgery of en dometrial cancer can destroy the vaginal microecological balance and increase the risk of vaginal stump infection, but chemotherapy can control long-term recurrence and metastasis of endometrial cancer, and prolong the survival time, and it is benefit for the long-term prognosis of women with endometrial cancer. It suggests that the prevention and control of vaginal microecological damage after chemotherapy should be paid attention to in clinical practice.
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