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| Correlation between TORCH infection in women during the second and the third trimester of pregnancy and the occurrence of birth defects |
| 1. Binzhou Maternal and Child Health Care Hospital, Binzhou, Shandong Province, 256600；2. Binzhou People's Hospital |
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Abstract To explore the correlation between TORCH infection and the lower genital tract infection of women during the second and the third trimester of pregnancy and the occurrence of birth defects. Methods: 3,594 pregnant women who had accepted TORCH examination were enrolled in this study from February 2015 to January 2019. According to the results of TORCH examination, these women were divided into group A (254 women with TORCH infection) and group B (3340 women without TORCH infection). All these women were followed up to delivery, and birth defects of their newborns were recorded. The rate of birth defects was compared between the two groups. The correlation between TORCH infection and birth defects was analyzed. Results: Among these 3594 pregnant women, there were 254 (7.07%) cases with TORCH infection, which included the highest infection rate of CMV was 3.53%, and then followed by that (1.53%) of TOX infection, and the other infections were low. Among 3594 newborns, there were 49 cases with birth defects, which included 44 cases with single malformation and 5 cases with multiple malformations, and the total incidence of birth defects was 13.63‰. The incidence of congenital heart disease (5.56%) was the highest, then followed by cleft lip and palate (3.90%), finger/toe malformation (1.67%), spina bifida (1.39%), and external ear malformation (1.11%). The incidence of birth defects of newborns in group A (14.96%) was significant higher than that (0.33%) of newborns in group B (P＜0.05). The incidence of congenital heart disease of newborns was positively associated with the infections of CMV, TOX, RV, and HSV of the pregnant women (r>0，P＜0.05), but had no correlation with other infections (P＞0.05). The incidence of cleft lip and palate was positively correlated with CMV infection (r>0，P＜0.05), but had no correlation with the infections of TOX, RV and HSV, and other infections (P＞0.05). The incidences of finger/toe deformity, spina bifida, and ear deformity were not correlated with TORCH infection (P＞0.05). Conclusion: The infections of CMV, TOX, RV, and HSV of pregnant women are associated with the congenital heart disease of their newborns, and the infection of CMV is associated with congenital cleft palate of their newborns. It suggests that TORCH infection examination should be paid attention to in clinical practice, and prevention and treatment of TORCH infection for women should be strengthen to reduce the occurrence of birth defects.
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