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| Analysis of the changes of prothrombin time, activated partial thromboplastin time, fibrinogen level, thrombin time, D-dimer level, and antithrombin Ⅲ level of pregnant women during different pregnancy |
| The First People’s Hospital of Hefei, Anhui Province, 230030 |
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Abstract To explore the changes of prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (Fib) level, thrombin time (TT), D-dimer level, and antithrombin Ⅲ (ATⅢ) level of pregnant women during different period of pregnancy. Method: 240 healthy pregnant women were selected in study group, and were divided into group A (80 women in the first trimester of pregnancy), group B (80 women in the second trimester of pregnancy), and group C (80 women in the third trimester of pregnancy) from January 2017 to December 2018. 50 healthy non-pregnant women were recruited in group D. The levels difference of PT, APTT, Fib level, TT, D-dimer level, and AT Ⅲ level of women were compared among the four groups. Result: The PT, APTT, and TT of women had decreased with the increasing gestational weeks of women (P＜0.05), but the PT and APTT of women had no significant different between group A and group D, and the PT of women had no significant different between group B and group C (P＞0.05). The Fib and D-dimer levels of women in group A, group B and group C had increased in turn (P＜0.05), but which had no significant different between group A and group D (P＞0.05). The AT Ⅲ level of women had no significant different between group A and group D and between group B and group C (P＞0.05), but which of women in group A was significant higher than that of women in group B (P＜0.05). Conclusion: The coagulation function of pregnant women changes with their increasing gestational weeks, which shows the women are in the state of high coagulation. The monitoring of the coagulation indexes of pregnant women should be paid more attention to, and the possible complications of pregnant women should be timely diagnosed and treated in clinic.
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