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| Levels of AMH and hyaluronic acid in follicular fluid of women with low ovarian reserve and their relevant to the results of oocyte retrieval |
| Jiyuan Maternal and Child Health Care Hospital, Henan Province, 459000 |
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Abstract To investigate the levels of antimullerian hormone (AMH) and hyaluronic acid in follicular fluid of women with low ovarian reserve, and to study their relevant to the results of oocyte retrieval. Methods: 190 infertile women were selected and divided into group A (42 low ovarian reserve) and group B (148 women with normal ovarian reserve) according to the ovarian reserve function evaluation criteria from January 2018 to March 2019. The AMH and hyaluronic acid levels in follicular fluid of women were measured and compared between the two groups. Results: The AMH level (1.22±0.32ng/ml), the hyaluronic acid level (280.92±68.82g/L), and the number of eggs retrieval (3.3±0.7) of women in group A were all significant lower than those of women in group B (P＜0.05). The levels of AMH and hyaluronic acid in follicular fluid were positively correlated with the number of eggs retrieval (r=0.618 and 0.358, P＜0.05). The area under ROC curve of the levels of AMH and hyaluronic acid in follicular fluid for predicting low ovarian reserve were 0.934 and 0.808, respectively (P＜0.05), and which’s cut off values were 1.73 ng/ml and 305.50g/L, respectively. The sensitivity of the levels of AMH and hyaluronic acid in follicular fluid for predicting low ovarian reserve were 91.2% and 82.5%, and the specificity of them were 90.0% and 78.0%, respectively. Conclusion: The levels of AMH and hyaluronic acid in follicular fluid of women with low ovarian reserve have certain relevant to their oocyte retrieval, which has some application value for predicting ovarian reserve function.
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