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| Observation of the clinical effect of pregnancy termination during the second trimester of pregnancy of women with advanced age |
| 1. Beijing Daxing District Maternal and Child Care Hospital, Beijing, 102600; 2. Peking Union Medical College Hospital |
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Abstract To explore whether advanced age (over 35 years old) of women increased the risk of pregnancy termination during the second trimester of pregnancy. Method: A retrospective analysis included 93 women who had experienced pregnancy termination during the second trimester of pregnancy by ethacridine lactate amniotic cavity injection in Peking union medical college hospital from 2013 to 2019. All these women had no the risk factors of pregnancy termination, such as medical complications, scar uterus, lactation, history of multiple induced abortions, and history of multiple hysteroscopic treatments. These women were divided into group A (women ≤35 years old ) and group B (women more than 35 years old). In group A, the women were given dinoprostone suppositories (DS) additionally in group A1 and the women were not given DS additionally in group A2. In group B, the women were given DS additionally were in group B1 and the women were not given DS additionally in group B2. The situations of pregnancy termination during the second trimester of pregnancy of the women were compared among these groups. Results: There were no statistically significant differences in the initiation time of uterine contraction, the fetal delivery time, the total labor time, the volume of 2h postpartum hemorrhage, and the rates of hemorrhage of induced labor, retained products of conception, injury of soft birth canal, additional uterine contraction intervention, postpartum infection, and induced labor success of the women between group A and group B (P>0.05). However, the cervical laceration of the women had occurred in both group A2 and group B2, and the hemorrhage of induced labor of the women had occurred in group B. The initiation time of uterine contraction and the fetal delivery time of the women in both group A1 and B1 had showed a shortening trend. Conclusion: Advanced age (>35 years old) does not increase the risk of the pregnancy termination of women. The ethacridine injection by transabdominal amniocentesis for terminating pregnancy during the second trimester of pregnancy of women with >35 years old was safety and effectiveness, and ethacridine combined with DS for induced labour may reduce the incidence of cervical lacerations.
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