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| Research progress of MAPK signal pathway in spontaneous abortion |
| Institute of Reproductive Medicine, Baotou Medical College, Inner Mongolia, 014040 |
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Abstract Spontaneous abortion is one of the pathological pregnancies, and its etiology and pathogenesis are complicated. Some of the causes have been generally accepted. However, there are still 50% of spontaneous abortions with unknown causes, and its pathogenesis is still unclear. In recent years, researches have found that the MAPK signal pathway plays an important role in embryonic development, trophoblast cells invasion, and decidual immune microenvironment. The occurrence of pathological pregnancy may be greatly related to the abnormal MAPK signal pathway. Therefore, this article will review the relationship between MAPK signal pathway and spontaneous abortion, in order to provide theoretical evidences for the clinical prevention and treatment of spontaneous abortion.
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