|
|
|
| Analysis of serum cytokine level, related risk factors, and pregnancy outcomes of pregnant women with group B streptococcus infection during the third trimester of pregnancy |
| 1. The Third Clinical College of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325000; 2. The Second Affiliated Hospital of Wenzhou Medical University |
|
|
|
Abstract To explore the serum levels of cytokines and pregnancy outcomes of pregnant women with group B Streptococcus (GBS) infection during the third trimester pregnancy, and to analyze the related risk factors of GBS infection. Methods: 800 pregnant women during 34-41 gestational weeks were included in this study, of which 400 women were infected by GBS in observation group and 400 women were not infected by GBS in control group. The serum levels of procalcitonin (PCT) and interleukin-6 (IL-6), and pregnancy outcomes of women were compared between the two groups. The risk factors of GBS infection of pregnant women were analyzed. Results: The levels of serum PCT and IL-6 of women in the observation group were 0.14 ±0.04 ng/mL and 15.14±1.67 pmoL/mL, which were significant higher than those of women in the control group (P＜0.05). Age, body mass index (BMI), gestational diabetes mellitus (GDM), vulvovaginal candidiasis (VVC), abortion history and delivery history of women were closely related to the occurrence of GBS infection (P＜0.05). Logistic regression analysis showed that advanced age, high BMI, GDM, VVC, abortion history, and delivery history were independent risk factors of GBS infection of women during the third trimester of pregnancy (P＜0.05). The incidences of premature delivery, intrauterine infection, premature rupture of membranes, amniotic fluid pollution, cesarean section, neonatal asphyxia and neonatal pneumonia of women in the observation group were 22.5%, 23.0%, 16.0%, 25.3%, 17.8%, 15.5%, and 3.5%, respectively, which were significant higher than those of women in the control group (P＜0.05). Conclusion: GBS infection can increase the level of serum inflammatory factors of pregnant women during the third trimester of pregnancy, and can increase the risk of adverse outcomes, such as premature delivery, intrauterine infection, and amniotic fluid contamination. Therefore, GBS screening and controlling should be strengthened, especially for those women with advance age, high BMI, GDM, VVC, abortion history, and delivery history, in order to reduce the GBS infection during the third trimester of pregnancy.
|
|
|
|
|
|
|
|
|
