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| Analysis of HPV infection of patients with different features of cervical lesions and its correlation with infertility |
| The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi Province, 710061 |
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Abstract To investigate human papilloma virus (HPV) infection of patients with different features of cervical lesions, and to study its correlation with infertility. Methods: 78 patients with cervical cancer were in group A, 65 patients with cervical intraepithelial neoplasia (CIN) were in group B, 62 patients with infertility were in group C, and 50 normal women were in group D. The HPV infection status and subtypes were detected by flow-through rapid hybridization. The relationship between cervical cancer pathology and HPV infection was analyzed. The characteristics of HPV infection in infertility were summarized, and the risk factors of high-risk HPV infection in infertile women were screened. Results: The rates of HPV infection and high-risk HPV infection of women in group A, B, and C were significant higher than those (20.0% and 12.0%) of women in group D, and those (92.3%、86.4%) of patients in group A were the highest (P＜0.05). There was no significant different in the multiple infection rate among the four groups (P＞0.05). The high-risk HPV infection rate of patients with stage III cervical cancer was significant higher than that of patients with stage Ⅰ and Ⅱ cervical cancer. The high-risk HPV infection rate and the multiple infection rate of patients with lymphatic invasion of cervical cancer were significant higher than those of patients without lymphatic invasion of cervical cancer (all P＜0.05). The first sexual life occurrence less than 20 years old and cervical erosion history were the risk factors of high-risk HPV infection of infertile patients (P＜0.05). Conclusion: The patient with cervical cancer or infertility has higher HPV infection rate and high-risk HPV subtype infection rate. The rate of HPV infection increases with the progression of cervical cancer. The smaller years old of women when their first sexual life occurrence and the cervical erosion history of women are both the risk factors of infection of infertile patients. So they should be paid attention to, and infection screening and treatment should be conducted in clinical practice.
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