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| Correlation between serum mir-146a level, estrogen level, or endometrial receptivity of women with PCOS and their pregnancy |
| Henan Institute of Population and Family Planning Science and Technology, Zhengzhou, Henan Province,450000 |
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Abstract To explore the correlation between serum mir-146a level, estrogen level, or endometrial receptivity of women with polycystic ovary syndrome (PCOS) and their pregnancy. Methods: From September 2016 to September 2018, 140 women with PCOS were selected in study group, another 110 women without PCOS who underwent ovulation treatment due to ovulation disorder during the same period were selected in control group. The serum samples of the women in the two groups were collected. The expression of miR-146a was detected by quantitative real-time PCR (qRT-PCR), and the levels of serum estradiol (E2), luteinizing hormone (LH), and follicle stimulating hormone (FSH) were measured by chemiluminescence immunoassay. The endometrial receptivity, the indexes, pulsation index (PI), resistance index (RI), and endometrial thickness (Em) of these women were measured by B-ultrasound. The women with PCOS were followed up for one year in outpatient service, and were divided into group A (71 women with pregnancy) and group B (69 women without pregnancy). Pearson test was used to analyze the correlation, and multivariate logistic regression was used to analyze the risk factors of pregnancy of women with PCOS after treatment. Results: The levels of serum Mir-146a, LH, and FSH PI, and the values of PI and RI of women in the study group were significant higher than those of women in the control group, but E2 level and Em value of women in the study group were significant lower (all P＜0.05). In the study group, the levels of serum Mir-146a, LH, and FSH, and the values of PI and RI of women without pregnancy were significant higher than those of women with pregnancy, but E2 level and Em value of women without pregnancy were significant lower (all P＜0.05). The levels of Mir-146a, E2, LH, and FSH, and the values of PI, RI, and Em of the women with PCOS were all the independent risk factors of pregnancy after treatment (P＜0.05). Conclusion: The levels of serum MiR-146a, LH, and FSH and the values of PI and RI of the women with PCOS decrease, which may affect the endometrial receptivity and participate in the occurrence and development of PCOS.
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