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Abstract To investigate the expression of cytokeratin 17 (CK17) in cervical lesions tissue of patients with different types of HPV cervical infection, and to study it’s relevant with high-risk HPV (HR-HPV) infection. Methods: 200 samples with liquidbased cytology abnormalities of patients between January 2014 and December 2018 were collected. The type of HPV was detected by gene chip hybridization technology. CK17 expression in tissues of cervical lesions was detected by immunohistochemistry. The differences of CK17 expression were compared among patients with different pathological grades of cervical lesions and among patients with different cervical HPV type infection. The relationship between CK17 expression and HR HPV infection was analyzed. Results: There was a statistically significant difference in HPV positive rate among patients with different pathological grades of cervical lesions (P＜0.05). A total of 14 HPV types were detected, which included 11 types of HR HPV (16, 18, 31, 33, 45, 51, 52, 53, 58, 66, and 68) and 3 types of low risk HPV (6, 11, and CP8304). The proportion of 16 type HPV infection of patients with different cervical lesions was the highest. In the tissues of chronic cervicitis, CIN or cervical cancer, the positive expression rate of CK17 was increased with the increasing of lesion grade (P＜0.05). The CK17 positive expression rate in cervical tissues of patients with HPV 16/18 and 52/58 infection were 51.6% and 33.3%, which had statistically significant difference from that (25.8%) of other types of HPV infection. CK17 positive rate of patients with HR HPV infection was significant higher than that of patients with low risk HPV infection (all P＜0.05). Spearman correlation analysis showed that CK17 expression was positively correlated with HR HPV infection (r=0.176, P=0.022). Conclusion: CK17 has expression difference in cervical lesions tissue of patients with cervical different types of HPV infection, and CK17 expression level has a weak positive correlation with HR HPV infection.
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