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Abstract To investigate the influence of gonadotropin releasing hormone (GnRH-alpha) combined with laparoscopy for treating women with endometriosis on their levels of retinol binding protein 4 (RBP4), tumor specific growth factor (TSGF), and angiopoietin receptor 2 (Tie-2). Method: 300 women with endometriosis were divided into group A (150 women treated by GnRH-alpha combined with laparoscopic) and group B (150 women treated by laparoscopic treatment only). The efficacy, safety, and the RBP4, TSGF and Tie-2 levels before and after treatment of women were compared between the two groups. Results: The effective rate (94.7%) of women in group A was significant higher than that (74.7%) of women in group B. The recurrence rate, and the levels of RBP4, TSGF and Tie 2 of women in group A were 2.0%, 13.82±2.03 g/L, 40.36±4.99U /L, and 23.04±3.06mg/L, respectively, which were significant lower than those (18.0%, 18.02±3.02 g/L, 55.23±7.27U /L, 33.23±4.09mg/L, respectively) of women in group B (all P＜0.05). There was no significant difference in the incidence of adverse reaction (2.0% vs.0.0%) of women between the two groups (P＞0.05). Conclusion: GnRH-alpha combined with laparoscopy for treating women with endometriosis can significantly reduce their levels of RBP4, TSGF and Tie-2, and reduce the recurrence of endometriosis, which’s effect is better than that of laparoscopy used alone.
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