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Abstract To investigate the changes and the significance of autoimmune mechanism and ovarian blood flow parameters of women with premature ovarian failure (POF). Methods: 100 women with POF were selected in study group, and 100 healthy women with normal menstrual cycles were selected in control group. The number of CD4+ and CD25+ regulatory T cells (Treg) , serum interferon gammaγ(IFN-γ) level , and the values of ovarian interstitial peak flow velocity (PSV), resistance index (RI), and maximum ovarian planar mean diameter (MOD), antral follicle number (AFC), and levels of serum follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) of women were detected and compared between the two groups. Results: The values of AFC and MOD，E2 level, the number of Treg in peripheral blood, and ovarian interstitial PSV value of women in the study group were significant lower than those of women in the control group, but the levels of serum FSH, LH and IFN-γ, and PSV value of women in the study group were significant higher (all P＜0.05). In the study group, the peripheral blood Treg count was positively correlated with ovarian interstitial PSV value, but was negatively correlated with RI value and IFN-γ level (P＜0.05). Serum FSH level of women with POF was negatively correlated with Treg count and ovarian interstitial PSV value, but was positive correlation with RI value and IFN-γ level (all P＜0.05). Conclusion: The women with POF have significant immune disorders and changes of ovarian interstitial blood flow, which may lead to the changes of their reproductive hormone levels.
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