To investigate the correlation between lipid metabolism of pregnant women with preeclampsia and their disease progression. Methods: The data of 90 pregnant women with preeclampsia were collected from August 2017 to December 2018, which included group A (50 women with mild preeclampsia) and group A (40 women with severe preeclampsia). Meanwhile, another 30 normal pregnant women were selected in group C. The levels of lipid metabolism (TC, TG, LDL, HDL), serum inflammatory related factors levels (PON-1, Lp-PLA2, TNF-α, CRP, IL-6, APN), and vitamin A and E levels of women in the three groups were observed. The neonatal outcomes of the three groups were recorded. And the correlation between lipid metabolism and the progression of preeclampsia was analyzed by Spearman correlation analysis. Results: The levels of serum TC, TG, LDL, Lp-PLA2, TNF-α, CRP, and IL-6 of women in group C, group A, and group B had increased in turn, but the levels of HDL, PON-1, and APN, and placental weight, amniotic fluid contamination rate, neonatal Apgar score at 1 min after born, and neonatal weight had decreased in turn (P<0.05). Conclusion: The level of lipid metabolism of pregnant women with preeclampsia is abnormal, and the lipid metabolism index is closely related to preeclampsia. The lipid metabolism of pregnant women should be paid more attention to in clinical practice for preventing preeclampsia.