To investigate the effect of age on pregnancy outcomes of women experienced vaginal delivery after last cesarean section. Methods: The clinical data of 1126 women with successful vaginal delivery after last cesarean section from January 30, 2016 to June 30, 2019 were analyzed retrospectively. These women were divide group A (850 women＜35 years old ) and group B (276 women≥35 years old). The clinical data and pregnancy outcomes of women in the two groups were observed, and the influencing factors of adverse pregnancy outcomes were analyzed. Results: The time of this pregnancy to last delivery of women in group B was significant longer than that of women in group A, and pre-pregnancy BMI value, and the rates of gestational hypertension and gestational diabetes of women in group B were significant higher (P<0.05). 240 women had adverse pregnancy outcomes, which include the highest incidence of postpartum hemorrhage. The incidences of premature delivery, infant Apgar score <7 points at 5 min after born, and low birth weight of neonates in group B were significant higher than those in group A (P<0.05). Univariate analysis showed that the proportions of advanced age, history of abortion,  high pre-pregnancy BMI, gestational hypertension, and history of stillbirth of women with adverse pregnancy outcomes were significant higher than those of women with normal pregnancy outcomes (P<0.05). Multivariate analysis showed that advanced age［OR（95%CI）：2.104（1.203-8.157）］, gestational hypertension［OR（95%CI）：1.238（1.023-4.123）］, history of stillbirth［OR（95%CI）：1.456（1.244-6.347）］ and times of pregnant examination［OR（95%CI）：1.526（1.334-7.149）］were independent risk factors for adverse pregnancy outcomes of women with cesarean section history when trial to vaginal delivery (P<0.05). Conclusion: Vaginal delivery for women with cesarean section history is safety and feasible, but the incidence of adverse pregnancy outcomes is high in woman with advanced age, so times of pregnant examination of woman with advanced age should be increased for reducing.