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Abstract To investigate the influence of vitamin D combined with individualized exercise and dietary intervention on islet β-cells and pregnancy outcomes of pregnant women with gestational diabetes mellitus (GDM). Methods: From January 2016 to December 2017, 86 pregnant women with GDM were included in this prospective study, and they were divided into control group and observation group (43 cases in each group) by random number table method. All women in the two groups were given insulin aspart subcutaneous injection, and the women in the observation group were given oral vitamin D3, individualized exercise and dietary intervention additionally. The related parameters of blood sugar, the inflammatory factor levels, the ischemia and hypoxia related indicators, the levels of serum homocysteine (HCY) and serum cystatin C (Cys-C), the indicators related to islet beta cells, and the rates of adverse pregnancy and fetal outcomes were compared between the two groups. Results: There were no significant different in related blood glucose indicators, inflammatory factor levels, ischemia and hypoxia related indicators, levels of HCY and Cys-C, and related indicators of islet-βcell before treatment between the two groups (P>0.05). After treatment, the levels of FPG, 2hPG, HbAlc, hs-CRP, TNF-α, HIF-1α, ET-1, Bax, Caspase-3, HCY, Cys-C, FINS, and HOMA-IR of women in the observation group were significant lower than those of women in the control group, but the levels of NO, HOMA-β and ISI were significant higher than those of women in the control group (P<0.05). And the rates of adverse pregnancy outcomes and adverse fetal outcomes of the observation group were 23.3% and 23.3%, which were significant lower than those (58.1% and 44.2%) of the control group (P<0.05). Conclusion: Vitamin D combined with individualized exercise and dietary intervention can effectively improve the blood glucose control effect of pregnant women with GDM, can decrease their level of serum inflammatory factors, can relieve their placental ischemia and hypoxia, can enhance their islet β cell function, and can improve their pregnancy and fetal outcomes.
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